01 / 02Safety Planning
Antidote Pen
Responsible CORE protocol planning includes having the Antidote Pen on hand.
Specifications
Key Attributes
- Essential safety tool for all CORE Trimix protocol users
- 10 doses at 20 clicks per dose — adequate response support for protocol emergencies
- Vasoconstrictor mechanism — opposes the vasodilatory effect of CORE compounds
- Compact pen format for discreet access when needed
- Private access in Bangkok and throughout Thailand alongside CORE pen orders
Biohackr.Labs provides product education, protocol guidance, and private client support. Information on this website is not medical advice and does not replace consultation with a licensed healthcare professional.
What's Included
Premium hard case.
Everything included.
Every Biohackr.Labs pen ships in our premium white hard case — holographic logo, foam-fitted interior. Inside: the precision pen, ten individually sealed 31G 8mm micro needles, and all documentation needed to begin your protocol correctly.
Precision pen
Pre-filled, batch quality-controlled pen system ready at your confirmed starting dose.
10× 31G micro needles
31G 8mm individually sealed sterile micro needles. Ten included as standard with every pen.
Protocol card
Starting dose, titration schedule, session guidance, and what to expect — specific to your protocol.
Batch QC documentation
Batch reference, preparation date, and compound specification. Not boilerplate — specific to your order.
Storage & handling guide
Temperature requirements, travel guidance, and handling notes with Bangkok climate context.
WhatsApp support access
Direct channel access throughout your protocol for questions, dose adjustments, and guidance.
Cold-Chain Delivery
Professionally packed
for Bangkok logistics.
Every Biohackr.Labs order is individually sealed, temperature-controlled, and dispatched in protective cold-chain packaging engineered to maintain product integrity from preparation to your door.
2–8°C maintained
Insulated inner liner and cold-pack keep the product in range throughout Bangkok transit.
Discreet outer packaging
Plain kraft outer box — no branding, no product name, no external indication of contents.
Tamper-evident sealing
Every product is individually sealed before dispatch. Integrity is visible at handover.
Step 01
Protocol Overview
“Responsible CORE protocol planning includes having the Antidote Pen on hand.”
The Antidote Pen is a Priapism Response Support pen providing 10 doses of response compound — 20 clicks per dose — for use in the event of a prolonged or painful erection that does not resolve within the expected timeframe. Priapism — an erection lasting more than 4 hours — is a medical emergency. The Antidote Pen is not a treatment substitute for emergency medical care; it is an intermediate support tool for responsible CORE protocol planning. All CORE users should have an Antidote Pen accessible before beginning any CORE protocol.
Step 02
How It Works
The Antidote Pen contains a compound that acts through the opposing vascular pathway to the CORE Trimix mechanism — producing local vasoconstriction to reduce arterial inflow and support resolution of a prolonged erection. This reversal mechanism is well-established in clinical management of priapism and is the pharmacological basis for responsible CORE protocol safety planning.
Administration
Subcutaneous injection at the confirmed administration site if a prolonged erection occurs and does not resolve. Administer 20 clicks (one dose). If no resolution occurs within 30 minutes, seek emergency medical care immediately. The Antidote Pen is a response support tool — it does not replace urgent medical evaluation for priapism lasting more than 4 hours.
Titration Note
The Antidote Pen is not titrated. It is used at the confirmed single-dose level (20 clicks) in a response situation. If you have any questions about appropriate use, contact your private access support before your first CORE protocol session.
Who This Is For
Every CORE protocol client. The Antidote Pen should be ordered alongside any CORE Trimix pen. It is not optional for responsible CORE protocol use. Priapism risk exists across all CORE compounds at any dose — having response support immediately accessible is part of correct protocol setup.
Storage — Bangkok
Refrigerate between 2–8°C. Keep the Antidote Pen in the same accessible, refrigerated location as your CORE pen — it should be immediately available during and after any CORE protocol session. Do not leave it stored away from your session location.
Private Access Required
All CORE protocols require private client onboarding before product access is granted.
Request Discreet GuidanceThe Formula
What Is Trimix?
Trimix is a compounded three-compound intracavernosal formula that has been used in clinical urology for over three decades. Where oral medications like sildenafil (Viagra) or tadalafil (Cialis) work systemically through the bloodstream — producing effects that depend on sufficient nitric oxide production and intact vascular pathways — Trimix acts locally and directly at the target site. The three compounds work through complementary, synergistic mechanisms to produce a reliable, titratable local erectile response regardless of the systemic factors that limit oral medication effectiveness.
Trimix vs Oral Medications
Mechanism
Systemic (via bloodstream) — requires intact nitric oxide pathway
Local (direct cavernosal injection) — bypasses systemic limitations
Onset time
30–60 minutes (sildenafil) / up to 2 hours (tadalafil)
5–20 minutes typical
Effectiveness in vascular ED
Reduced or absent when vascular disease limits nitric oxide production
Effective regardless of nitric oxide pathway integrity
Interaction with food/alcohol
Reduced absorption with high-fat meals (sildenafil)
Not affected by food or alcohol intake
Dose control
Fixed tablet doses — no titration
Precision per-click titration to individual response threshold
Triple Mechanism
What Each Component Does
Primary vasodilator
Alprostadil (PGE1)
Prostaglandin E1 binds directly to receptors in cavernosal smooth muscle, activating adenylyl cyclase and increasing cyclic AMP — which relaxes smooth muscle, increases arterial inflow, and initiates the erectile response. Alprostadil is the active agent in multiple FDA-approved topical and injectable formulations for erectile response support. As the primary component of Trimix, it produces the foundational local vasodilatory effect.
Non-selective PDE inhibitor
Papaverine
Papaverine inhibits phosphodiesterase enzymes non-selectively — preventing the breakdown of both cyclic AMP and cyclic GMP in smooth muscle cells. This amplifies and prolongs the relaxation signal initiated by alprostadil, extending the duration and reliability of smooth muscle relaxation in the corpus cavernosum. Papaverine has been used in intracavernosal therapy since the 1980s and is the oldest clinical compound in the Trimix combination.
Alpha-adrenergic blocker
Phentolamine
Phentolamine blocks alpha-adrenergic receptors — the receptors responsible for sympathetically mediated vasoconstriction. Under stress, anxiety, or sympathetic nervous system activation, alpha-adrenergic tone can counteract the vasodilatory effect of the other compounds. Phentolamine prevents this, ensuring consistent smooth muscle relaxation regardless of psychological or sympathetic state. This is why Trimix can produce reliable response even in contexts where psychological factors have previously limited effectiveness.
Why Titration Matters
CORE Trimix protocols require careful individual dose titration because the response to intracavernosal compounds varies significantly between individuals — and the consequence of over-dosing is priapism, a medical emergency. There is no universal starting dose. Individual response depends on baseline vascular tone, compound sensitivity, concurrent medications, and psychological factors. Private onboarding confirms your starting dose before your first session. Titration increases this dose incrementally across sessions until your effective dose is identified. Do not skip titration or assume a dose from community forums — the risk is not the ineffectiveness of an underdose, but the danger of an overdose.
The Antidote Pen Is Not Optional
Every CORE protocol client should have an Antidote Pen accessible before beginning any session. This is not a precaution for high-dose users only — priapism risk exists at any dose and in any session, including those at established doses that have previously produced normal responses. The Antidote Pen provides immediate pharmacological response support while emergency medical care is being arranged.
Understanding Priapism Risk
Priapism — a prolonged, painful erection lasting more than 4 hours — is a medical emergency that can result in permanent vascular damage if untreated. All CORE compounds carry this risk at any dose level. The risk is managed, not eliminated, through careful titration and having the Antidote Pen immediately accessible. Seek emergency medical care immediately if an erection becomes painful, lasts longer than 4 hours, or does not respond to Antidote Pen administration within 30 minutes.
Administration Guide
Intracavernosal
Injection Technique
The following guide covers the two-step intracavernosal self-injection technique used with all CORE Performance pens. Review this guide fully before your first session and follow your protocol card for your specific starting dose.
Before You Begin
- Have your Antidote Pen accessible at all times
- Always alternate injection sides — 9–11 o'clock (left) or 1–3 o'clock (right)
- Never inject at 12 o'clock or 6 o'clock positions
- Start at the lowest recommended dose
- Seek urgent medical care immediately if erection lasts more than 4 hours
This guide is provided for educational reference and is specific to CORE Performance pen administration. Always follow the written protocol card provided at handover. If you have any questions about technique or your starting dose, contact us via WhatsApp before your first session.
CORE Range
Other CORE Performance Pens
Discreet Private Access
CORE male performance support in Bangkok and throughout Thailand.
Request Discreet Guidance